Highway 113 serves as an east–west route in northwest Minnesota between Syre, the White Earth Indian Reservation, Waubun, and Clover Township.

The route passes through Clearwater County briefly twice in southern La Prairie Township.

The western terminus of Highway 113 is located in the Red River Valley region of Minnesota.

The eastern terminus of the route is located immediately south of Lake Itasca.

The section of Highway 113 between U.S. 59 at Waubun and U.S. 71 at Clover Township was authorized on April 22, 1933.