At the western terminus, upon crossing the Red River, the roadway continues westward as state highways numbered 200 all the way to Idaho, a total distance of about 1,356 miles (2,182 km).

The route runs across Minnesota from west to east, connecting Ada, Mahnomen, Walker, and Floodwood.

Highway 200 serves as an east–west route in northwest and northeast Minnesota between Halstad, Ada, Mahnomen, Walker, Remer, Hill City, and Floodwood.

Itasca State Park is located on Highways 200 and 71 at the headwaters of the Mississippi River.

Highway 200 was designated and signed c. 1969 as part of a link of state routes numbered 200 stretching from Minnesota to Idaho.