Highway 246 serves as an east–west and a north–south route between the communities of Northfield, Dennison, Nerstrand, and Kenyon in southeast Minnesota.

It follows a zigzag route running along section lines.

In the city of Northfield, Highway 246 follows Woodley Street W. and Division Street S. Highway 246 passes near the town of Dennison at its junction with County Road 31.

Nerstrand-Big Woods State Park is located near the junction of Highway 246 and Rice County Road 29 at Nerstrand.

The park entrance is located on County Road 29.