State Highway 25 serves as a north–south route in central Minnesota between Belle Plaine, Norwood Young America, Watertown, Buffalo, Monticello, Big Lake, Becker, Foley, and Brainerd.

The route travels east–west between Belle Plaine and Green Isle for 15 miles.

The route crosses the Highway 25 Bridge at the Mississippi River between Monticello and Big Lake.

State Highway 25 was authorized November 2, 1920 from Belle Plaine to Big Lake.

[11][12] In 2001, the northernmost segment of the highway between State Highway 210 and Merrifield was turned back to Crow Wing County maintenance[13] and is now designated County Road 3.