Minnesota State Highway 46 (MN 46) is a 46.377-mile-long (74.637 km) highway in north-central Minnesota, which runs from its intersection with U.S. Highway 2 near Deer River (northwest of Grand Rapids) and continues northwest to its northern terminus at its intersection with State Highway 1 in Northome.

Highway 46 serves as a northwest–southeast route between the communities of Deer River, Squaw Lake, and Northome.

The roadway passes through the Chippewa National Forest in Itasca County.

The route is legally defined as Legislative Route 165 in the Minnesota Statutes.

[3] By 1953, there was one remaining gravel section in the middle of this route.