Highway 57 serves as a north–south route in southeast Minnesota between Kasson, Mantorville, Wanamingo, and Hader.

Two miles north of Kasson, the route enters historic Mantorville and goes by some landmarks, such as the Hubbell House.

North of Mantorville, Highway 57 is very lightly traveled and doesn't enter another incorporated city for twenty miles (32 km).

The route is also known as Main Street in the cities of Mantorville and Wanamingo.

The route was extended south of the original terminus in Kasson in 1980 to meet the U.S. 14 bypass.