State Highway 60 serves as an east–west marked route in southern Minnesota between Worthington, Windom, St. James, Mankato, Faribault, Zumbrota, and Wabasha.

In North Mankato, Highway 60 moves from a concurrency with U.S. 169 to another one with U.S. Highway 14, continuing east on a four lane expressway until just past Eagle Lake, where the route leaves U.S. 14 and continues briefly north to Madison Lake then northeast towards the city of Faribault.

State Highway 60 was formed in 1934 by connecting three Minnesota constitutional route segments together.

This formed a nearly border-to-border state highway, with its original termini at current U.S. 59 in Worthington and U.S. 61 at Wabasha.

The route was extended to the Iowa state line in 1937, and was authorized onto the bridge to Wisconsin in 1943.