Minnesota State Highway 72 (MN 72) is a 76.810-mile-long (123.614 km) highway in northwest Minnesota, which runs from its intersection with U.S. 71 in Blackduck and continues north to its northern terminus at the Canada–US border in Baudette.

State Highway 72 serves as a north–south route between the communities of Blackduck, Shooks, Kelliher, and Baudette.

The roadway passes through the Red Lake State Forest in northeast Beltrami County between Kelliher and Waskish.

Big Bog State Recreation Area is located on Highway 72, immediately north of Waskish.

State Highway 72 was authorized as one of the first two Minnesota legislative routes in 1923.