However, some studies show that Minuane ancestry is present in some Argentinian people living in Entre Rios.

[citation needed] In 1583, the conquistador Juan de Garay was killed in battle against the Minuane nation.

In 2 campaigns in 1749 and 1750 the governor of Santa Fe, Francisco Antonio de Vera y Mujica, invaded Minuane territory and massacred them in today's city of Victoria in Entre Ríos.

Many survivors were captured and translated to the province of Santa Fe, forming a reserve in Cayasta.

In 1751, the governor of Montevideo, José Joaquín de Viana killed 120 Charruas-Minuane in Uruguay.