In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression.

[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034).

Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme.

In this case, the mature sequence is excised from the 3' arm of the hairpin.

It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.