[2] From 1996 to 2011, Mencacci relocated to Rome, where in 1999 he established a secondary arm of SAM studios, providing post-production services for cinema.

Mencacci's story inspired the Italian autobiographical film Red like the Sky which was directed Cristiano Bortone in 2002.

[11] His work has also featured and been exhibited at the Guggenheim in New York City, MOMA, Pompidou in Paris, MAXXI Museum in Rome, and the Venice Biennale with films including Michelangelo's Eye to Eye by Michelangelo Antonioni, Puccini and the Girl by Paolo Benvenuti.

He has been involved in the recording of jazz, classical, pop and experimental music from artists including Benson Taylor, Blonde Redhead, Playing for Change, Luke Winslow-King, Niia, Stefano Bollani, Anthony Sidney, Mauro Refosco, Tony Scott, Sportfreunde Stiller, Irio de Paula, Nguyên Lê, Kazu Makino, Ornella Vanoni, Nada[30] Marina Rei, Il Teatro degli Orrori, Paolo Fresu, Enrico Rava, Bruno Tommaso, Nada, Stewart Copeland, Giovanni Caccamo, Riki (Riccardo Marcuzzo), Zen Circus, Bandabardò, One Dimensional Man, Tooth, Emma Morton, Thegiornalisti, Mauro Ermanno Giovanardi, and many others.

[31] Mencacci regularly hold master classes on sound in cinema across Europe and at international educational institutions including universities & film festivals.

[32] He participated as a speaker on the experimentation of Spherical Sound, and the system of sound recording at Artevisione with Sky and Careof in Milan in 2016,[33] Centro Professione Musica at CPM in Milan,[34] and the Cinekid[35] festival in Amsterdam in 2016, Festival du film de Beauvais in Paris in 2012, Ear to the Earth in New York City in 2006.