She made her professional acting debut at age four, reciting poems and reading stories on The Uncle Gee Bee Kiddie Hour on WGBS, one of New York's first radio stations.

[1] She joined the repertory acting company in 1934 and remained with the program well into her adult years, playing spooky witches, wicked and wise queens, good and bad spirits, kind and cruel mothers and stepmothers.

At 12, Wolfe auditioned to succeed the 79-year-old Adelaide Fitz-Allen in the part of the ancient witch-narrator Old Nancy on Alonzo Deen Cole's The Witch's Tale (on the Mutual Broadcasting System).

Cole, puzzled at first when he saw a young girl in a straw hat and Buster Brown haircut, hired her as soon as he heard the spine-chilling, cackling laugh which became her trademark.

In the 1950s, Wolfe became a weekly regular on The Rayburn & Finch Comedy Hour and Popeye the Sailor (CBS Network), where she played both Olive Oyl and the Sea Hag for several seasons.

Wolfe also learned Blissymbolics, wrote teachers' guides and directed a weekly workshop for the Ontario Gifted Children's Program.