Mirpur Mathelo (Sindhi:میرپور ماٿيلو‎) is a city in Ghotki District, Sindh province, Pakistan.

In Mirpur Mathelo town, a Technical and IT Institute Siscom Technologies (https://www.siscomtek.com/) and a library is also present.

Masu Vah (Canal) flows in the suburb of the city just near the site of Fauji Fertilizer Company Limited.

Ten Kilometers between this city and Daharki has major Pakistani industries i.e. Fauji Fertilizer Company Limited, Mari Gas Company, Liberty Power Plant and Engro Fertilizer Plant of Engro Corporation.

[4] According to the final results of the 2017 Pakistani census, 95.19% of the population spoke Sindhi, 1.30% Saraiki, 1.09% Punjabi and 1.06% Urdu as their first language.

Other languages which include Kashmiri, Balochi, Hindko, Pashto and Brahui, made up 1.34% of the population.

FFC has also provided a lot of Job Opportunities for Mathelians and has thus improved the conditions of the area since its establishment in 2002.