Until 1861/62, he managed the private finances of Naser al-Din Shah (r. 1848–1896).

He was afterwards appointed to three offices; amin-e khalwat, the custodian of the personal estate of the shah, which was a newly created title and office which would remain exclusive to the Ghaffari family; the chief of the court personnel; the commander of the royal musketeers; and the dean of the shah's household.

In 1871, a seat in the government's Consultative Assembly was granted to Mirza Hashem Khan.

Later that year, following the death of Mirza Hashem Khan's brother Farrokh Khan in May, Nasir al-Din Shah appointed him vazir-e hozur and bestowed upon him his brother's title of Amin od-Dowleh.

[1] Mirza Hashem Khan died in 1877 and was buried in the city of Qom.