Mirza Yusuf Ashtiani (1812 – 7 April 1886; Persian: میرزا یوسف آشتیانی) also known as Mostowfi ol-Mamalek (مستوفی الممالک) was the Grand Vizier of Iran during the reign of Nasser al-Din Shah and one of the most influential members of Qajar bureaucratic system at that time.

Mirza Yusuf Ashtiani, as one of the most influential members of Nasser al-Din Shah's court, played a role in many important events of his time, including the removal of Mirza Mohammad Khan Sepahsalar,[1] the poisoning of Hossein Gholi Khan Ilkhani,[2] the establishment of the Qajar bureaucracy and the expansion of Tehran.

Later, he became the tutor of Kamran Mirza, the young son of the Shah, a job that was equivalent to the government of Tehran and the director of real estate.

[6] After that, his sphere of influence and power gradually increased, until Nasser al-Din Shah became acquainted with the reformist ideas of Mirza Hosein Khan Moshir od-Dowleh.

[7] After the exile of Mushir al-Dawla, Mirza Yusuf served as Grand Vizier informally from 1880 and formally from 1884 until his death in 1886.

[12] During the reign of Mirza Yusuf, Nasser al-Din Shah gradually disregarded the duties of the monarchy and increasingly sought refuge in isolation and his own interests within Harem.