It is run by the Sisters of Mercy and operated under the auspices of the Archdiocese of Chicago.
[1] It began as a maternity hospital for women of meager means in 1921, and expanded to serve young children with developmental disabilities by 1954.
[2] In 1976 the Angel Guardian Orphanage on 2001 Devon Avenue closed, and a portion of that land was given to Misericordia Home.
[3] In 2016 the organization opened up for care of elderly people with disabilities.
[5][6] The following year, in 2023, Misericordia House's former executive director Sister Rosemary Connelly, R.S.M.