A member of the House of Saud, he held different cabinet posts in the 1950s and was the chairman of the Allegiance Council from 2007 to 2017.

[4] Their mother was an Armenian woman, Shahida, (died 1938),[5] who reportedly was the favorite wife of King Abdulaziz.

[12] Because of Mishaal's considerable power, King Abdulaziz countered his influence by appointing Abdullah bin Faisal as minister of health and interior.

[12] Prince Mishaal's tenure as minister of defense ended in 1956 when he was dismissed by King Saud because of his alleged pro-Nasserist views and corruption claims.

[16] Mishaal bin Abdulaziz protested more than once that he should have been crown prince since he served as both a governor and a minister and was older than some of his brothers.

This role was considered to be a significant position, giving him influence in the decision-making process in regard to succession.

[18] Mishaal bin Abdulaziz was a leading businessman, with substantial investments in real estate, insurance, electrical utilities, oil trading and cement manufacture.

Al Shoula's wholly owned subsidiary, Dhahran Global, is active in broad areas of the petroleum and petrochemical industry including pipeline development, oil and gas production, oilfield services and international product trading.

[23] The CEO of Al Shoula Group was his son Prince Abdulaziz[23] who was appointed to the post in the late 1990s.

In the early 1970s Prince Mishaal allocated land in Mecca for the foundation of charities which would assist Palestinian families whose children had been killed during the operations against Israel.

[33] In October 2009 Mishaal bin Abdulaziz was rushed to hospital in Geneva, apparently having suffered a stroke.