Skelton started taking piano lessons in third grade, and in high school she was involved in musical theater and choir competitions.

After she met her husband, music producer Alex Otey, they began playing in jazz, folk and rock bands together.

The members have each earned their President's Active Life Style Awards and are experienced musicians who have performed rock, jazz, funk and classical music.

[14] Miss Amy performed as part of the White House 2010 Egg Roll event on April 5, 2010, where the theme was based on the Let's Move!

[15] Other performers at the 2010 White House Egg Roll event included Justin Bieber,[4] J.K. Rowling, and the cast from Glee.

[3] 2011's Miss Amy's Fitness Rock & Roll was produced by Otey's husband and co-creator, Alex, and released on his label, Ionian Productions.

The album features James Popik on guitar and vocals, Chris Clark on bass, Andy Janowiak and Rick Vinet on percussion, saxophonists Richie Cole and Tom Verde, and brass player Lars Wendt.

"[6] She has appeared on television spots such as NBC 10!,[13] and in March 2013 Shine On Hollywood Magazine presented her as one of the "Top Women Entertainment Industry Professionals.

In 2013 she released Angels Riding Shotgun, the debut album of the Americana rock band Off the Map With Miss Amy.

[16] Miss Amy is an active member of the National Academy of Recording Arts & Sciences and the Americana Music Association.