It has been serialized in Ichijinsha's seinen magazine Manga 4-Koma Palette from 2014 until 2022, after which it was moved to Monthly Comic Rex before concluding the same year.

An audio drama based on the manga was released in 2016, and an anime television series adaptation by Silver Link aired in 2018.

The series follows Aki Shiina who, wanting to reaffirm his identity as man after being teased for his feminine looks, moves to the Sunohara-sou lodging house in Tokyo.

Wanting to reaffirm his identity as a man, he moves to the lodging house Sunohara-sou in Tokyo, and forms a crush on its motherly caretaker Ayaka Sunohara; his plan does not go smoothly, as Ayaka and the other residents – Yuzu Yukimoto, Sumire Yamanashi and Yuri Kazami of the Tanamachi student council – often tease him and make him wear women's clothes, while he keeps getting read as a girl.

[9] After the magazine ended in February 2022, Miss Caretaker of Sunohara-sou was moved to Ichijinsha's Monthly Comic Rex where it continued its run before concluding the same year.

Sato aimed to make her portrayal of Ayaka come across as easy-going and gentle, while Kitamura aimed to portray Aki as innocent and pure, describing him as at times similar to "a small animal"; she thought that this was helped by how she is a woman, and that a male actor would have resulted in the character leaving a different impression.

[39] They considered several of the characters a bit overbearing for being clingy and harassing, though, including Maiko and Mea, Nana, Matsuri, Sumire, and Ayaka, but still found them entertaining.