A 10-episode anime television series adaptation by Silver Link aired on Tokyo MX between July and September 2013.

After a series of battles, Illya and Miyu were able to collect all Cards and became good friends, while Rin and Luvia remained in Japan by the order of Zelretch.

Illya supplies Kuro with the mana needed to sustain her physical form, and accepts her into the Einzbern family.

Shortly afterwards, the group is attacked by Bazett Fraga McRemitz, who was previously responsible for obtaining the Class Cards.

The group confronts the eighth Class Card, Gilgamesh, who reveals that Miyu hails from a parallel world where she was born as a Holy Grail, before absorbing her.

Illya combines the Kaleidostick Ruby and Sapphire to become Kaleido Liner Zwei, giving her the power to defeat Gilgamesh and save Miyu.

The series, written by Hiroshi Hiroyama, was serialized in Kadokawa Shoten's Comp Ace magazine from September 2007 to November 2008.

In 2010, a special chapter was serialized in Comp Ace to celebrate the magazine's fifth anniversary, featuring a crossover between Prisma Illya and Magical Girl Lyrical Nanoha.

In September 2024, Seven Seas Entertainment announced that they had licensed the first series in a single omnibus volume for English publication in February 2025.

[6] The first season, a 10-episode anime television series adaptation by Silver Link, aired in Japan between July 13 and September 14, 2013.

The ending theme for episode 9 is "Tsunagu Kizuna - Tsutsumu Kodoku" (ツナグキズナ・ツツムコドク, Connected Bonds Seals Loneliness) by StylipS.

The anime is licensed in North America by Sentai Filmworks, who released the series on Blu-ray Disc and DVD on September 2, 2014.

An animated film based on the series, Fate/kaleid liner Prisma Illya: Vow in the Snow, was released on August 26, 2017.