Missandei is portrayed by Nathalie Emmanuel in the HBO television adaptation, where her role is greatly expanded from that in the books.

[4] Missandei is working as an interpreter for Astapori slaver Kraznys mo Nakloz when Daenerys Targaryen comes to inspect his army of Unsullied.

When Barristan Selmy seizes control of Meereen, he has Missandei tend to the mortally wounded Quentyn Martell.

[9] She has also discussed Missandei's romance with Grey Worm, calling it "endearing" and remarking on the pleasure of working with co-star Jacob Anderson.

In season 5, Grey Worm is gravely wounded in a skirmish with the Sons of the Harpy, and Missandei stands vigil by his side.

Daenerys subsequently flies away on Drogon,[11] and Daario Naharis decrees that Tyrion, Missandei, and Grey Worm should govern Meereen in her absence.

Later, as the Unsullied prepare to leave for the seizure of Casterly Rock, Missandei goes to Grey Worm to talk about their feelings and the pair consummate their relationship.

Feeling unwelcome amongst the Northerns, she and Grey Worm plan to sail to Naath after Daenerys wins the Iron Throne.

After the defeat of the White Walkers, she accompanies Daenerys' forces to Dragonstone, but they are ambushed by Euron Greyjoy's fleet and Missandei is taken prisoner and brought to Cersei Lannister in King's Landing.

[13] Although many viewers considered Daenerys's transition into a mad conqueror to be poorly executed by the show's creators, she would go on in the next episode to use Drogon to destroy the city of King's Landing and kill a large portion of its inhabitants.

[13][14] Missandei's death was viewed by some as an easy shortcut to Daenerys's improbable flip and the subsequent destruction of King's Landing.

[16] After her death, Grey Worm was the only major character of color for the remainder of the series, aside from the unnamed new Prince of Dorne.