The episode was written by showrunners Jed Whedon and Maurissa Tancharoen and directed by series star Clark Gregg.
He stars alongside Ming-Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Henry Simmons, Natalia Cordova-Buckley, and Jeff Ward.
"Missing Pieces" originally aired on ABC on May 10, 2019, and was watched by 3.63 million viewers within a week of its release.
The surviving hostiles from the anomalies are there and destroy the museum to make way for their leader, Sarge, who is revealed to be a lookalike of Coulson.
[2] With the start of filming in July 2018, the sixth-season premiere was revealed to be titled "Missing Pieces", written by showrunners Jed Whedon and Maurissa Tancharoen.
[8] At 2018 San Diego Comic-Con, main cast members Ming-Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Henry Simmons, and Natalia Cordova-Buckley were confirmed to return from previous seasons as Melinda May, Daisy Johnson / Quake, Leo Fitz, Jemma Simmons, Alphonso "Mack" Mackenzie, and Elena "Yo-Yo" Rodriguez, respectively.
[14] In April 2018, Barry Shabaka Henley was announced as cast as natural science professor Marcus Benson.
[16] Osinski, Venskus, Stoffer, and Henley guest star in the episode alongside Lucas Bryant as Keller, Winston James Francis as Jaco, Matt O'Leary as Pax, Brooke Williams as Snowflake, Glenn Keogh as Trok, and Levi Meaden as Fox.
[3] After the emotional fifth-season finale, Wen felt that returning for the sixth season with Gregg directing was "wonderful out of the gate, and like we got a new life".
[21] The effect of Sarge's crew appearing through the handball court wall was created by CoSA VFX, and inspired by different videos of objects being pushed through barriers.
[5] The episode began streaming on Netflix in the United States on September 1, 2019, along with the rest of the sixth season.