[3] Declared by the state legislature in 1854 to be a navigable stream, it retains the designation today, even though most of it was vacated for use by boats in 1874 and later filled in.

[4] Soil liquefaction, such as that which killed numerous people in the 1906 San Francisco earthquake, has been known to occur along buried portions of the creek.

[5][6] The China Basin Building was erected on the creek's north bank in the 1920s and used for off-loading and processing bananas through the 1950s.

In the 1970s it was known as the Del Monte Building and used as a food distribution site by the Hearst family in response to the demands of the SLA.

[8] The mouth of Mission Creek has been known to Major League Baseball fans as McCovey Cove ever since the year 2000 when the San Francisco Giants relocated from their former home at Candlestick Park to Oracle Park on the creek's north bank.