The center of Mission Creek is generally considered at the junction of Pine County 61 with Tie Road, and Railroad Lane; located in the northern portion of Mission Creek Township (population 635).

Nearby places include Hinckley, Beroun, and Brook Park.

Mission Creek is six miles east-northeast of Brook Park.

Also nearby is the junction of Interstate 35, State Highway 23 (MN 23), and Pine County 61; just south of Hinckley at the Mora exit.

ZIP codes 55037 (Hinckley) and 55007 (Brook Park) meet near Mission Creek.