The Laguna Creek watershed consists of 25.1 square miles (100 km2) of land within northern California's Alameda County.

Agua Caliente, Canada del Aliso, Mission, Morrison, Sabercat, Vargas, and Washington creeks drain the area of the watershed.

[5][6] At the time of the Spanish settlement and the construction of Mission San José, groundwater was still readily available through the porous sandstone in the area.

[7] The watershed still has many of the plants and trees native to the area, including valley oak,[8] Frémont's cottonwood, and California sycamore.

Mud Slough debouches into the San Francisco Bay near the site of the ghost town of Drawbridge.