Mission Hill is a town in Yankton County, South Dakota, United States.

[9] According to the United States Census Bureau, the town has a total area of 0.33 square miles (0.85 km2), all land.

The racial makeup of the town was 98.3% White, 1.1% Native American, and 0.6% from other races.

21.7% of all households were made up of individuals, and 4.3% had someone living alone who was 65 years of age or older.

16.9% of all households were made up of individuals, and 2.8% had someone living alone who was 65 years of age or older.

About 7.5% of families and 12.3% of the population were below the poverty line, including 27.1% of those under the age of eighteen and none of those 65 or over.