[1][2] The mission was officially founded on March 1, 1700 by Sargento mayor Diego Ramón, with Franciscan missonaries Antonio de Olivares and Francisco Hidalgo in attendance.
It was originally located 5 miles (8.0 km) from the Rio Grande in Coahuila state, northeastern Mexico, in what is today the Municipality of Guerrero.
The Terocodame and Xarame tribes were the most numerous; other groups present included the Jaram, Papanac, Payaguá, and Kumeyaay.
In December, he reported that the natives had left the mission, due to food shortages and the danger from raids.
Olivares traveled to Mexico City to ask Ramón for support, returning with a military company and two additional missionaries, Jorge de Puga and Alonso González.