Francisco de Villagra crossed the Andes through Mamuil Malal Pass and headed south until reaching Limay River in the vicinity of Nahuel Huapi Lake.
Diego de Rosales started his journey at the ruins of Villarica in Chile, crossed the Andes through Mamuil Malal Pass, and traveled further south along the eastern Andean valleys, reaching Nahuel Huapi Lake in 1650.
[1] Until the wreckage of HMS Wager in Guayaneco Archipelago 1741 Jesuits clearly prioritized Nahuel Huapi Lake as an area to expand their missionary activity over the Patagonian islands south of Chiloé.
[1] The Franciscans who replaced the Jesuits in Chiloé sought to rediscover the route across the Andes to Nahuel Huapi Lake in order to establish a mission there.
[7] The conflictive Intendant of Chiloé Francisco Hurtado del Pino accused the Franciscans in 1787 of not being interested in missioneering, wrongly claiming the route to Nahuel Huapi was known.