The producers of Star Trek had issues with the book, as they were concerned that it was dull and poorly written, in addition to containing offensive descriptions of both Sulu and Uhura.

In Dr. McCoy's opinion, the Enterprise has been on patrol for such a long period of time that the crew is in danger of developing a form of space madness known as cafard.

Upon reaching the NGC 400 solar system, the Enterprise crew comes across three planets populated by different human settlers who had been unhappy with the social or political order of Earth.

These were followed the same year by short story adaptations of the episodes of Star Trek published by Bantam Books and written by James Blish.

There were concerns that Sulu had been described as a "bland faced, small oriental" and that Uhura was called a "negress" and sings a spiritual.

[7] Mission to Horatius was reprinted as a facsimile edition by Pocket Books in February 1999 to ostensibly celebrate the publisher's 20th anniversary as a Star Trek licensee.

Editor John J. Ordover stated, when interviewed for Jeff Ayers' Voyages of Imagination, that it was reprinted for fun, and that when pitched he had explained that Paramount Studios held the rights to the book as Whitman had gone out of business.