The Missionaries of the Precious Blood (Latin: Congregatio Missionariorum Pretiosissimi Sanguinis) is a Catholic community of priests and brothers.

Members do not take vows but are held together by the bond of charity only and by a promise of "fidelity to the Congregation of Missionaries of the Precious Blood in accordance with its Constitution and Statutes, giving [themselves] entirely to the service of God": see the formula of incorporation found in C37 of the Normative Texts 2008.

[4] Saint Gaspare del Bufalo founded the society at the request of Pope Pius VII, who was shocked by the spiritual situation in Rome after he returned from exile.

In 1814, he selected del Bufalo and some other priests to undertake the responsibility, assigning them to the abbey of San Felice at Giano dell'Umbria, in the Umbria region of Italy.

In the 1860s the Italian Government suppressed some twenty-five houses of the society,[5] including the Maria in Trivio property and confiscated the revenues of the seminary at Albano.

The Kulturkampf (1871–1878), enacted by the prime minister of Prussia Otto von Bismarck against the Catholic Church, closed the houses in Alsace and in several German-speaking states.

The society continued to prosper throughout and communities were established in Spain (1898), Brazil (1929), Chile (1947), Peru (1962), Tanzania (1966), Guatemala (1976), Croatia (1979), Poland (1982), India (1985), Mexico (1995), Vietnam (1997) and Colombia (2005).

[9] In North America the Missionaries of the Precious Blood minister to those who have experienced family violence and those who live in socio-economically deprived cities such as Chicago.

[12] After Vatican II (1962–1965) the society made a concerted effort to minister in more areas of Latin America as well as Africa and Asia.

In Tanzania the Canadian members of the society are specifically involved in assisting people to establish and maintain projects such as healthcare, improved agriculture and education.

As of 2015: Provinces: Atlantic (Canada), Cincinnati, Iberian (Spain and Portugal) Italy, Kansas City, Poland, Tanzania and Teutonic (Austria, Germany and Liechtenstein).

This spirituality of the Blood continues to impel us to build community through the inclusion of the marginalized, to walk in solidarity with those who suffer, and to seek reconciliation in a divided world".

The society, which has maintained its purpose of bringing the Gospel to where it considers it is most needed, declared: We are united by a bond of charity and rooted in the Spirituality of the Blood of Jesus.

In our willingness to be flexible and responsive to changing needs, we fulfill our mission through: • supporting and nurturing one another • embracing a life of prayer • calling forth the gifts of the laity and working in collaboration with them • preaching and witnessing the word of God • promoting conversion and reconciliation