It travels east–west for 91.1 miles (146.6 km) from MS 7 at Oxford, Mississippi to the Natchez Trace Parkway in Mingo near the Alabama state line.

It heads east briefly as a four-lane divided highway through a business district before narrowing to two-lanes and passing through neighborhoods for several blocks.

The highway now leaves Oxford and passes through farmland for a couple miles before entering the Holly Springs National Forest, where it travels through remote woodlands (passing by Puskus Lake Recreation Area) as it crosses into Union County.

The highway enters the New Albany city limits and passes through an industrial area before some neighborhoods and business district at an interchange with I-22/US 78 (Exit 61), where MS 30 becomes concurrent (overlapped) with the Interstate.

The highway passes through more hilly for a few more miles before coming to an end at an interchange with the Natchez Trace Parkway at the community of Mingo, with the road continuing south as County Road 85 (CR 85) towards Bloody Springs and the Alabama state line.