The road starts at MS 25 in Belmont, and travels southeastward through Golden to the Alabama state border.

The route travels southeastward out of the town, through farmland and small areas of trees.

Near the center of the village, the route intersects the eastern terminus of MS 760.

After passing County Road 78, MS 366 ends at the Alabama state line.

The new, paved route started from MS 25 and ended at the Alabama state line.