It was designated in 1956, starting at MS 1 south of Scott, and ending at Choctaw.

MS 450 is located in southern Bolivar County,[2] and is maintained by the Mississippi Department of Transportation (MDOT).

The route soon crosses the Great River Railroad and intersects First Street, a road that leads to Scott.

About one mile (1.6 km) later, the route turns east, and Stringtown Road continues south.

A few miles later, MS 450 enters the unincorporated town of Choctaw, where it intersects the old routing of US 61.

[13][14] By 1967, MS 450 connected from Stringtown to south of Scott instead, with the spur route being removed.