The route, which is also partially designated as the Jason Boyd Memorial Highway, was first established in 1956, and it became fully paved in 1965.

The southern terminus of MS 489 lies near the eastern edge of Scott County at an intersection with US 80, near Lake High School.

Much of the following part of the highway is filled with large, open pastures, until the route enters a forested section about four miles (6.4 km) later.

[5][6] Later, the road crosses over Conehatta Creek again and passes a mix of landscapes and geographic features, including Stamper Pond.

[6][10] On August 24, 2022, a short section of the highway near Conehatta was completely washed away as a result of major flooding in the area, causing the roadway to be closed.