The highway starts at U.S. Route 45 (US 45) near Porterville, and it travels eastward from its western terminus.

[2] In 2017, the Mississippi Department of Transportation (MDOT) calculated 370 vehicles traveling on MS 498 east of Dan Whitsett Road on average each day.

MS 498 travels eastward from the intersection, then east-northeast to Dan Whitsett Road inside a forested area.

[5] State maintenance ends several yards before a crossing over a railroad operated Kansas City Southern Railway.

[10][11] The remaining section east of Porterville was removed from the state highway system by 1970.