The road intersects the entrance to Natchez–Adams County Airport before ending at U.S. Route 61 (US 61).

MS 554 was temporarily removed from the highway system in 1967, but was added back in 1973.

The route continues traveling east until it reaches its eastern terminus at US 61.

[3][4] In 2013, Mississippi Department of Transportation (MDOT) calculated as many as 500 vehicles traveling west of Howard Loop, and as few as 290 vehicles traveling west of Old Meadow Road.

[12][13] MS 554 was removed from state highway maps in 1967,[14][15] and didn't reappear until 1973.