Heading east along Main Street into town (just past its crossing of the Okatoma Creek, the road passes some stores, homes, and churches.

In the center of Seminary, MS 590 has the road name of Main Street and crosses a railroad at-grade.

Towards the east side of town, it intersects MS 535 at its southern terminus.

Once leaving town, the highway heads east through a mix of woods, open fields, poultry farms, and houses.

MS 590 briefly parallels I-59 but then turns to the east to head around the north side of Jaycee Evaluation Center and Ellisville State School.