US 11 heads to the northeast in the community of Nicholson, where it parallels the Norfolk Southern Railway tracks.

US 11 and the railroad tracks continue to the north and intersects with West and East Canal streets in the center of Picayune.

US 11 continues northward into the community of Ozona, paralleling an original alignment, which is signed to the east.

After the county crossing, Red Top Road merges in, and the route begins paralleling the nearby railroad tracks.

US 11 enters the city of Lumberton once crossing the county line then heads to the local community of Seneca.

The highway continues to the northeast, entering the community of Talowah and passes through the city of Purvis.

US 11 next enters the downtown area, the route surrounded by commercial buildings and paralleled by nearby railroad tracks.

Paralleling nearby railroad tracks, US 11 crosses under the MS 42 expressway, which has an interchange with US 11; the route soon becomes less developed and leaves Petal.

The route leaves Dragon and begins a slight curve to the northwest, still paralleling the railroad tracks.