MS 606 and Beach Boulevard begin at a dead end in the parking lot of Silver Slipper Casino in the seaside community of Lakeshore, near the outlet of Bayou Caddy.

According to the Mississippi Department of Transportation (MDOT), the formal southern terminus is further south where a parking lot formerly existed, but had since been removed for an expansion of the casino building.

[2] The road heads north along the immediate sandy shoreline of the Mississippi Sound, part of the Gulf of Mexico, to have an intersection with Lakeshore Road (which leads to the main part of the community, Bayside Park, and U.S. Route 90 or US 90) before curving northeast to leave Lakeshore and cross Sand Bayou to pass through the community of Clermont Harbor, where it crosses a couple more bayous (one of which is Grand Bayou) and travels through Buccaneer State Park.

North Beach Boulevard and MS 606 continue around the west side of Bay St. Louis heading between a residential neighborhood and small private fishing piers and boat clubs.

The road and MS 606 ends at the Cedar Point Boat Launch within view of Hollywood Casino Gulf Coast.