It crosses Bogue Phalia as it travels through Pace, where it has an intersection with MS 817, before continuing east for several miles to enter Cleveland.

The highway passes by Delta State University as it travels through neighborhoods along W Sunflower Road.

MS 7/MS 8 follow along the south bank of the Yalobusha for several to enter Grenada, where they widen to a four-lane undivided boulevard and pass through an industrial area.

The highway then crosses the Yalobusha for the final time to enter Calhoun City, where MS 8 splits off to pass through Derma at a traffic circle in downtown (which is also where it meets the other end of Old Highway 8 (Veterans Avenue), which leads to the village of Big Creek).

The highway now leaves Houston and jogs southeast for a few miles to have an interchange with the Natchez Trace Parkway.

MS 8 passes northeast through farmland for a few miles before entering the wooded Appalachian Foothills, bypassing Athens to the south before coming to an end at an intersection with US 278 (former MS 6) at the community of Wise Gap, near the Alabama state line.

It split off the current alignment at Futheyville at the intersection with MS 333 Scenic, headed east to pass through what is now Hugh White State Park, and followed the Yalobusha River to pass through Big Creek before entering downtown Calhoun City along Veterans Avenue.