It heads through flatlands for several miles to become concurrent with MS 8, as well as crossing Topashaw Creek and the Yalobusha River, before entering Calhoun City.

The two highways split at a Traffic Circle in the center of town, with MS 8 splitting off along Veterans Avenue, and MS 9 continues north along Main Street to pass through some neighborhoods before leaving Calhoun City and winding its way through hilly terrain to travel through the village of Pittsboro before crossing the Skuna River into Bruce.

MS 9 leaves Pontotoc at an interchange with US 278/MS 6, where it widens to a four-lane divided expressway, and heads northeast through hilly areas to travel through the community of Endville.

The highway enters Sherman after an intersection with Magnolia Way (unsigned MS 780), with the expressway end at an interchange with I-22/US 78 (Exit 76).

The highway winds its way through town along Main Street, where it has an intersection with County Road 278 (CR 278, unsigned MS 764).