Missouri's 1st congressional district is in the eastern portion of the state.

With a Cook Partisan Voting Index rating of D+27, it is the most Democratic district in Missouri.

[2] Roughly half of the district's population is African American.

Its current representative is Democrat Wesley Bell, who was first elected in 2024.

William Lacy Clay, Jr., had previously represented the district between 2001 and 2021, succeeding his father, William Lacy Clay, Sr. For the 118th and successive Congresses (based on redistricting following the 2020 census), the district contains all or portions of the following counties and communities:[4] Independent cities (1) St. Louis County (59)