Missouri's 2nd Senatorial District is one of 34 districts in the Missouri Senate.

The district has been represented by Republican Nick Schroer since 2023.

[2][3] The district is based in south-central St. Charles county, falling within the northwestern side of the St. Louis metropolitan area.

[2] Major municipalities in the district include Cottleville, O'Fallon, and Lake St. Louis.

The district is also home to the historic Daniel Boone Home.