The office also administers the Homeland Security Program and state and federal funds in grants for juvenile justice, victims' assistance, law enforcement, and narcotics control.

The Division of Alcohol and Tobacco Control is responsible for alcoholic beverage excise tax collection, liquor licensing along with liquor and tobacco enforcement, and providing training to licensees in these areas.

The Missouri State Highway Patrol Division is responsible for law enforcement on state highways and waterways, criminal investigations, criminal laboratory analysis, motor vehicle and commercial vehicle inspections, boat inspections, and public education about safety issues.

The Capitol Police serve as the primary law enforcement agency for the capitol complex, as well as other state buildings in Jefferson City, patrolling the buildings and grounds 24 hours a day, seven days a week.

The Division of Fire Safety provides training and certification to firefighters and emergency response personnel, investigates fires across the state, and has responsibilities related to the safety of fireworks, elevators, explosives, amusements rides, day care centers, and boilers.