As a result of the 2022 elections, the Democratic Party controls none of Missouri's statewide offices for the first time since Reconstruction.

The conflicts, mainly due to the dysfunctional relationship between Senator Jim Reed and President Woodrow Wilson, led to a disruption for the Missouri Democratic Party, degrading the party to minority status throughout most of the 1920s.

[3] Among the supporters for Reed were mainly Irish immigrants settled in the urban part of Missouri.

[5] In the 2010 elections, the Missouri Democratic Party won three of the nine House of Representatives districts.

The voters of Missouri have voted against the eventual winner four times in the presidential elections, favoring Adlai Stevenson over Dwight Eisenhower in 1956, John McCain over Barack Obama in 2008, Mitt Romney over Barack Obama in 2012 and Donald Trump over Joe Biden in 2020.

[8] Harry S. Truman is probably the most influential person in the history of the Missouri Democratic Party.

The backing of the organization helped Truman secure Missouri's senator seat in the 1932 election.