It passes through Cooper, Pettis, and Morgan counties.

Southbound Route 135 runs concurrent with eastbound US 50 in Pettis and Morgan counties, with northbound Route 135 running concurrent with westbound US 50 over the same portion of US 50.

Ozarks International Raceway is located along the highway.

[1] It serves Laurie, Proctor, Stover, Florence and Pilot Grove.

This Missouri road-related article is a stub.