While nearing the Meramec River, the highway has an at-grade intersection with Old Missouri State Road.

[2] In Valley Park, Route 141 passes over, and then under, a pair of railroad tracks and has several at-grade intersections with local road.

Heading north, the highway passes the Valley Park water tower and abruptly turns northwest.

The highway then has a SPUI with Missouri Route 100 (Manchester Road) while heading directly north.

Route 141 then has a hybrid trumpet interchange with Clayton Road and briefly becomes a controlled-access highway.

[2] The highway curves northeastwards, passing Parkway Central High School, which is located to the west of the road.

Shortly after passing the school, Route 141 curves back northward and heads through a wooded area.

Route 141 becomes elevated after the interchange, crossing over Creve Coeur Creek and several other streams, and passing a neighborhood to the west.

Subsequent progress included a new bridge over the Meramec River at Valley Park in 1986 and a new interchange at Manchester Road in 1999.

The section of Route 141 between Interstate 64 and the St. Louis County/Jefferson County line was upgraded to six lanes in a project completed in 2003.

The section between Page and Olive (tentatively titled the Page-Olive Connector), which was constructed by St. Louis County has been turned over to the Missouri Department of Transportation and designated as Route 141.

DHT held studies of the environment to decide how to maneuver construction without disturbing some of the native wetlands in the corridor.

[4] During heavy rain, the current intersection at Creve Coeur Mill Road and Olive has the potential to flood, and most of the area along Creve Coeur Mill Road are either wetlands or farmland that lies in a flood plain.