The four-lane road turns southwest as Gravois Rd and, after about two miles (3.2 km), intersects Route 366.

Shortly after the intersection with Route 366, the road becomes a narrow street passing through some older parts of St. Louis.

About two miles (3.2 km) further west is the intersection with Lindbergh Boulevard (U.S. 50 / U.S. 61 / U.S. 67) and the road becomes a four-lane divided highway.

A portion of the highway over the Meramec River was re-routed in the early 2000s when a new, wider bridge was built.

The southern half of MetroBus Route #10 (Lindell-Gravois) follows Gravois Ave from the Civic Center Station at 14th and Spruce, then onto Tucker and Chouteau.