Route 145 is a short highway in Mercer County, Missouri.

Route 145 begins at an intersection with US 136 west of Princeton, heading north on a two-lane undivided road.

The route passes through agricultural areas with some trees, curving northwest and running to the east of Lake Paho.

The road heads west and crosses the lake, continuing through more rural areas.

[2] The entire route is in Princeton, Mercer County.