Its southern terminus is at US 160 in Gainesville in Ozark County.

It then passes through Sycamore, past the Hodgson Mill and continues northeast.

It then heads due north through Dora in Ozark County and meets Route 14.

The route then runs concurrent with Route 14 for 4.8 miles (7.7 km) until meeting the twin bridges at the North Fork River and Spring Creek.The two bridges on Route 14 are separated by an 880-foot-wide (270 m) low point in a north–south trending ridge between the North Fork River and its tributary Spring Creek to the east.

It interchanges with US 60 before crossing over the Big Piney River and reaching its northern terminus at US 60 Business.